This paper provides an overview of cyberbiosecurity threats in relation to high-containment laboratories (HCLs). This include cybersecurity concerns HCLs, where cyberphysical elements and critical data pose unique risks. As part of the emerging field of cyberbiosecurity, the study presents a novel approach for assessing cybersecurity risks and identifying mitigation strategies within biological research, biotechnology, biomanufacturing and diagnostic environments. Using an asset-impact analysis, the research identifies common cyber and cyberphysical systems in HCLs and maps potential adverse outcomes from system compromises. The study further examines risk mitigation strategies, and aim to raise awareness among laboratory decision-makers and provide a structured approach to integrating cyber risk management into existing biorisk protocols.