he 2022 WHO Global guidance framework (Global guidance framework for the responsible use of the life sciences: mitigating biorisks and governing dual-use research ) for the responsible use of the life sciences calls for the implementation of measures to mitigate biorisks and safely govern dual-use research in the life sciences.  This course aims to enable key stakeholders across the entire life sciences research ecosystem to identify dual-use risks and ways in which they can be minimized as both an individual and collective responsibility and provide guidance on building a robust culture of the responsible use of the life sciences. The learning objectives for this training course are to define dual-use research (DUR), dual-use research of concern (DURC), and the responsible use of the life sciences (RULS); describe the key elements of the framework used to mitigate biorisks, govern DUR and DURC, and promote a culture of responsible life sciences research; identify how stakeholders across the life sciences research ecosystem can anticipate, mitigate, and prevent biorisks and effectively govern dual-use research that may pose risks to humans, animals, plants, agriculture, or the environment; and apply knowledge gained in the course through case studies and guided questions.